Beilstein J. Org. Chem.2017,13, 1039–1049, doi:10.3762/bjoc.13.103
important to the activities of cycloheximide congeners.
Keywords: antifungal activity; cycloheximidederivatives; E/Z photoisomerization; Streptomyces sp; theoretical conformational analysis; Introduction
The glutarimide-containing antibiotics represent a fascinating class of natural products that exhibit
of cycloheximidederivatives (4 vs 6) [21][22], and suggested that 2,3-dehydrogenation might result in the loss of the activity (1 vs 5, 6). The cytotoxicity of these isolates against human lung epithelial carcinoma (A549), human cervical epithelial adenocarcinoma (HeLa), and human breast carcinoma
findings suggested that these cycloheximidederivatives possibly exert the antifungal and cytotoxic activities via a similar mode of action.
Conclusion
Three new (1–3) and three known (4–6) cycloheximide congeners were obtained from the cultures of Streptomyces sp. SC0581. The structure elucidation of the